Princeton University - Latest News Update, Information, Photos & Videos on Princeton University at Lokmat Times

New York, Nov 19 Some ancestral rodents likely had repeated infections with SARS-like coronaviruses, leading them to acquire tolerance or resistance to the pathogens, raising the possibility that modern rodents may be reservoirs of SARS-like viruses, according to a new study.In the study, researchers at the Princeton University in the US, performed an evolutionary analysis of the ACE2 receptors used by SARS viruses to gain entry into mammalian cells, across mammalian species.The results, published in the journal PLOS Computational Biology, showed that primates had highly conserved sequences of amino acids in the sites of the ACE2 receptor known to bind SARS viruses.Rodents, however, had a greater diversity, and an accelerated rate of evolution, in these spots.Overall, the results indicated that SARS-like infections have not been evolutionary drivers in primate history, but that some rodent species have likely been exposed to repeated SARS-like coronavirus infections for a considerable evolutionary period.Some rodent species may have acquired some form of tolerance or resistance to infections from SARS-like coronaviruses, while non-adapted mammals and primates may be more susceptible to symptomatic disease."Our study suggests that ancestral rodents may have had repeated infections with SARS-like coronaviruses and have acquired some form of tolerance or resistance to SARS-like coronaviruses as a result of these infections," said Sean King, from the varsity's Department of Molecular Biology."This raises the tantalizing possibility that some modern rodent species may be asymptomatic carriers of SARS-like coronaviruses, including those that may not have been discovered yet," added Mona Singh from the Lewis-Sigler Institute for Integrative Genomics at PrincetonWhile all previous human coronaviruses have clear zoonotic origins, some studies and experts have claimed that SARS-CoV-2, the virus that causes Covid-19 infection, has also jumped from a non-human animal to humans.Previous research has shown that Chinese Horseshoe bats are a host of numerous SARS-like viruses and tolerate these viruses without extreme symptoms. Thus, identifying other animals that have adapted tolerance mechanisms to coronaviruses is important for awareness of potential viral reservoirs that can spread new pathogens to humans, the researchers said.Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Princeton UniversityFOLLOW

Princeton university, Latest News

Washington [US], June 4 : Researchers discovered that strengthening protection for areas already protected by law or by local ... ...

Washington [US], June 3 : In order to mitigate biodiversity loss, researchers discovered that strengthening protection for areas already ... ...

Researchers at Stevens Institute of Technology, working with Princeton University and the University of Chicago, have now directed an AI algorithm to model the first impressions and use facial photographs to accurately predict how people will be perc ...

A recent research has identified how carbon is stored and transported through the intricacy of inland and coastal waterways. ...

A new study led by Princeton University identified how carbon is stored and transported through the intricacy of inland and coastal waterways. The study has significant implications for enforcing the carbon calculations that are part of international ...

According to a study led by Princeton University researchers, the secret to how birds -- such as peacocks and hummingbirds produce brilliant shimmering colours lies in a key feature of the feather's nanoscale design. ...

BY VISHAL GULATI New Delhi, Dec 2 Researchers led by Princeton University investigated how different climate scenarios and ... ...

New York, Nov 19 Some ancestral rodents likely had repeated infections with SARS-like coronaviruses, leading them to acquire ... ...