The Dow Jones Industrial Average fell 115.98 points, or 0.43 per cent, to 26,806.14. The S&P 500 decreased 14.46 points, or 0.48 per cent, to 2,975.95, Xinhua news agency reported.
The Nasdaq Composite Index declined 63.41 points, or 0.78 per cent, to 8,098.38.
Shares of Boeing slid over 1.33 per cent after Saudi Arabian budget airline Flyadeal said it will cancel its order for Boeing's grounded 737 Max jets, which was worth $5.9 billion.
Shares of Apple fell nearly 2.1 per cent, as US brokerage firm Rosenblatt Securities downgraded the company's stock to sell from neutral, citing "fundamental deterioration" of its shares due to gloomy iPhone sales and slowing growth in Apple's other products.
A slew of the blue-chip stocks in the Dow extended losses around the closing bell, with shares of US pharmaceutical giant Merck & Co and its counterpart Pfizer dropping 1.82 per cent and over 1.41 per cent respectively, among the worst performers.
Six of the 11 primary S&P 500 sectors traded lower around market close, with the communication services sector down over 0.8 per cent, leading the laggards.
A better-than-expected jobs report last Friday has dimmed hopes for more easing momentary policy by the US central bank.
Yet Wall Street has still broadly expected the Fed to cut rates at its policy meeting on July 30-31.
US employers added 224,000 jobs in June, and the unemployment rate edged up to 3.7 per cent, the US Bureau of Labor Statistics reported on Friday.
The reading was markedly higher than May's downwardly revised number, and was higher than market forecast.
( With inputs from IANS )