Depp's star, which was unveiled in 1999, had three words scribbled on it using a black marker, reports dailymail.co.uk.
Someone has written 'phoney' just above his name, along with the curse words a** and b**** in-between his name and the gold film emblem. It appears that star was defaced sometime on Thursday (September 26).
It's not the first time the Walk Of Fame has been vandalised, with members of the public frequently scrawling on US President Donald Trump's star, and Mariah Carey's star being graffitied back in 2017.
Depp got famous with classic horror film "Nightmare On Elm Street" in 1984, followed by his sting on TV show "21 Jump Street". He went onto feature in projects such as "Charlie and the Chocolate Factory", the "Pirates of the Caribbean" franchise, "Arizona Dream", "Finding Neverland", and "Sweeney Todd: The Demon Barber Of Fleet Street".
His memorable roles gave him the title of third highest-grossing actor in the world, as films featuring Depp have grossed over $3.7 billion in the US and more than $10 billion worldwide.
At present, he is going through a rough patch in the wake of his films getting bombed, negative press that includes accusations of domestic abuse during his marriage to Heard. He has also claimed that she stubbed out a cigarette on his face and severed his finger with a glass bottle back during thier time together.
There have been several lawsuits against him, and accusations of epic spending that has reportedly caused him some major financial problems.
Recently, Deep was spotted promoting his latest much-anticipated film "Waiting For The Barbar" at the Venice Film Festival. His next drama film "Minamata" is currently in post-production, and is slated to be released in 2020.
( With inputs from IANS )