Wang, who is here for the 74th session of the UN General Assembly, made the remark on Tuesday while addressing a dinner co-hosted by the National Committee on US-China Relations, the US-China Business Council, the American Chamber of Commerce and the Council on Foreign Relations, Xinhua news agency reported.
China is still the largest developing country in the world and seeking hegemony has never been in its DNA, he said.
In response to the so-called "shift of international power" hyped by some in the US, Wang said that such a claim was a strategic misjudgment about China and reflects a lack of self-confidence.
In a world confronted with more and more challenges, no country could do well in isolation or fix all the problems single-handedly, Wang said, noting that the sharing of international responsibilities is a natural trend.
In this process, each country, big countries in particular, can harness its comparative strength and play a role to the best of its ability, he said, adding that China was ready to fulfil its due share of responsibilities.
The State Councillor also said that it was important for the us to avoid picking another misguided fight with the wrong country.
The ups and downs in China-US relations provide ample evidence that confrontation and conflict is not in the fundamental interests of both sides, and dialogue and cooperation is the only way to go, he added.
( With inputs from IANS )