The incident took place on Friday night and the accused has been identified as Rahisul Azam (34).
According to the statement issued by Delhi Police, Azam works at a footwear shop in Jahangirpuri and had a fight with his wife identified as Gulshan (39) over their children's future.
"He hit her with a stick on the head after which she died," a statement said.
Sub-Divisional Magistrate has registered a case in this regard.
The Chief District Medical Officer (CDMO) was also informed later as the area is under the COVID-19 containment zone.
Further investigation is underway.
( With inputs from ANI )