New Delhi, Feb 19 Young adults are more susceptible to the impact of nicotine, as their bodies are more sensitive to the dangerous and highly addictive chemical than middle-aged adults, according to a new study.
In a mice study, researchers from the Pennsylvania State University in the US showed that the effects of drugs on the body -- both medication and misused substances -- change as per age.
They stressed the need to consider this factor when developing and prescribing treatments against nicotine. The findings, appearing in the journal Behavioral Pharmacology, showed that nicotine lowers the body temperature of young adult mice more quickly and reduces their movement more significantly than middle-aged mice.
Further, young adult mice -- aged two months – were found to respond more acutely to a nicotine dose of the same strength relative to their body size than middle-aged mice -- aged eight months.
These results indicate how the effects of nicotine change as people age, said the researchers.
"People continue to develop and change across their entire lifespan, and this affects how our bodies respond to medications and other chemicals, including nicotine. This research adds one piece to the puzzle of all the factors -- age, biological sex, genetics, and many others -- needed to create effective medical treatments and policies for all people," said Thomas Gould, Professor of Biobehavioral Health and head of Penn State Department of Biobehavioral Health.
In the study, both young adult and middle-aged study subjects displayed decreased movement after receiving nicotine, but young adults reduced their movements more than middle-aged subjects. This indicates that the young adult subjects experienced the effects of nicotine more intensely, the researchers said.
The study shows that the younger a person is, the more acute is the response to nicotine. This has implications both for prevention messages and for supporting young nicotine users who want to quit.
Increased susceptibility to nicotine may also spike the risk of developing an addiction that can have serious health implications, said the team.
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