Bc cancer research institute, Research institute in Heidelberg, Germany

London, July 23 The antimalarial drug chloroquine widely rumoured to help prevent Covid-19 is not able to prevent infection of human lung cells with the novel coronavirus, say German researchers.The current study, published in the journal Nature, revealed that chloroquine is, therefore, unlikely to prevent the spread of the virus in the lung and should not be used for the treatment of Covid-19."In this study, we show that the antiviral activity of chloroquine is cell type-specific and that chloroquine does not block the infection of lung cells," said study researcher Stefan Pohlmann from German Primate Centre (DPZ) in Germany.It is known that SARS-CoV-2 is able to use two different routes to enter cells.First, after attaching to the cells, the virus can fuse directly with the plasma membrane and introduce its genetic material into the host cell. Second, it can enter the interior of the cells upon uptake via transport structures, called endosomes.In both cases, the attachment of the virus to the cells and subsequent entry is mediated by the viral spike protein.For this purpose, the spike protein must be activated either by the enzyme cathepsin L (in endosomes) or by the enzyme TMPRSS2 (on the cell surface).Depending on the cell type, both enzymes or only one of them can be available for activation.Since chloroquine inhibits the infection of monkey kidney cells with SARS-CoV-2, chloroquine has been tested in clinical trials as a possible candidate for the treatment of Covid-19.However, how chloroquine inhibits the infection of monkey kidney cells was not clear.The current study shows that chloroquine inhibits viral entry into these cells, most likely by blocking cathepsin L activity.This raised the question of whether chloroquine also inhibits the infection of lung cells that are known to produce TMPRSS2 but only a small amount of cathepsin L.The study shows that chloroquine does not prevent SARS-CoV-2 entry into human lung cells and the subsequent spread of the virus in these cells."This means that in future tests of potential Covid-19 drugs, care should be taken that relevant cell lines are used for the investigations in order not to waste unnecessary time and resources in our search for effective Covid-19 therapeutics," Pohlmann added.Recently, a study published in the journal Annals of Internal Medicine, revealed that the famous anti-malarial drug hydroxychloroquine (HCQ) was ineffective for Covid-19 patients with early and mild symptoms.( With inputs from IANS )

Bc Cancer Research InstituteFOLLOW

Bc cancer research institute, Latest News

New observations by the NASA/ESA Hubble Space Telescope suggest that the unexpected dimming of the supergiant star Betelgeuse was most likely caused by an immense amount of hot material ejected into space, forming a dust cloud that blocked starlight ...

Pakistan Rangers personnel in more than 20 vehicles and ISI personnel in civilian clothes in five vehicles surrounded and raided the house of Sindhi leader Lala Aslam Pathan in Shikarpur city of Sindh on Wednesday. ...

Berlin, Aug 7 Starting Saturday, travellers from high-risk areas will have to undergo a mandatory COVID-19 test upon ... ...

Manchester, Aug 5 Manchester United Manager Ole Gunnar Solskjaer has said the team needs to win trophies now ... ...

Berlin, Aug 4 German President Frank-Walter Steinmeier has urged citizens to "show consideration, caution and responsibility" in the ... ...

Berlin, Aug 1 Seventy-seven per cent German citizens fear that a second COVID-19 wave would occur in the ... ...

Berlin, July 25 Samsung has partnered with the German Federal Office for Information Security (BSI), Bundesdruckerei (bdr), and ... ...

London, July 23 The antimalarial drug chloroquine widely rumoured to help prevent Covid-19 is not able to prevent ... ...