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GlaxoSmithKline plc is a British multinational pharmaceutical company headquartered in Brentford, London. Established in 2000, by a merger of Glaxo Wellcome and SmithKline Beecham, GSK was the world's sixth largest pharmaceutical company according to Forbes as of 2019, after Pfizer, Novartis, Roche, Sanofi, and Merck & Co.