Washington DC [US], July 22 : Researchers from Rutgers University have found that most persons with multiple sclerosis (MS) opt for oral drugs to manage their chronic and worsening neurological conditions.
This is probably because of a number of elements, such as consumer promotion, ease of use, and insurance companies' support.
“While two injectable therapies known as platform injectables, were once the mainstay of multiple sclerosis treatment, our study showed oral therapies became the predominate treatment for multiple sclerosis by 2020,” said Mackenzie Henderson, a postdoctoral researcher at the Rutgers Institute for Health, Health Care Policy and Aging Research (IFH) and the lead author of the study.
“Our investigation offers an important step in understanding the evolving treatment landscape for MS among US adults and children," he said.
The study, published in JAMA Neurology, examined a large and diverse sample of commercially insured adults and children in the United States to evaluate trends in the uptake of therapies between 2001 and 2020 for patients with MS, a chronic and progressive neurological disorder and the leading cause of nontraumatic disability among young and middle-aged adults.
In 2000, there were two medications approved for MS treatment in the US, but over the past 20 years, more than 10 new medications have been approved, according to researchers.
Research on how these approvals have changed clinical practice has been limited. The Rutgers study shows injectable therapies accounted for nearly 100 per cent of medications for MS patients in 2001, but by 2020 that decreased to about 25 per cent, with oral therapies rising sharply after their introduction in 2010.
Using commercial claims data from more than 100,000 patients with MS between 2001 and 2020, researchers analyzed injectable, infusion and oral treatment trends.
They found that oral medications increased sharply in popularity to become the preferable treatment for MS patients over infusion and injectable treatments.
Infusion therapies remained low in uptake, accounting for about 8 per cent of therapy initiations in 2020, and platform injectable therapy use declined almost 74 per cent throughout the study period, according to the researchers.
"Despite the availability and efficacy of infusion therapies for multiple sclerosis, we found that their utilization remained relatively low throughout the study period,” said Chintan Dave, a faculty member at the Center for Pharmacoepidemiology and Treatment Science (PETS) at IFH, an assistant professor with Rutgers Ernest Mario School of Pharmacy and a senior author of the study.
“This may be due to several factors contributing to this treatment decision by patients and clinicians, including the preference for more convenient oral therapies, the relatively recent introduction of infusion options, and considerations of safety and cost," he added.
Researchers said further this investigation offers a crucial step in understanding the evolving treatment landscape for MS patients and future research should evaluate the impact of new therapies as they emerge.
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