Brisbane [Australia], August 17 : Researchers at the University of Queensland revealed in pre-clinical studies that an injection of a certain blood factor can duplicate the positive effects of exercise on the brain.
Using old mice as a model, a team lead by Dr. Odette Leiter and Dr. Tara Walker from the University of Queensland's Queensland Brain Institute revealed that platelets, the tiny blood cells essential for blood clotting, release a protein that rejuvenates neurons in a manner comparable to physical activity.
“We know exercise increases production of new neurons in the hippocampus, the part of the brain important for learning and memory, but the mechanism hasn’t been clear,” Dr Leiter said.
“Our previous research has shown platelets are involved, but this study shows platelets are actually required for this effect in the aged mice.”
The researchers focused on exerkines, the biological compounds released into the bloodstream during exercise, which are believed to stimulate the exercise-induced response in the brain.
“We discovered that the exerkine CXCL4/Platelet factor 4 or PF4, which is released from platelets after exercise, results in regenerative and cognitive improvements when injected into aged mice,” Dr Leiter said.
Dr Walker said the findings have significant implications for the development of drug interventions.
“For a lot of people with health conditions, mobility issues or of advanced age, exercise isn’t possible, so pharmacological intervention is an important area of research,” she said.
“We can now target platelets to promote neurogenesis, enhance cognition and counteract age-related cognitive decline.”
The researchers said the next step is to test the response in Alzheimer diseased mice, before moving towards human trials.
“It’s important to note this is not a replacement for exercise,” Dr Walker said.
“But it could help the very elderly or someone who has had a brain injury or stroke to improve cognition.”
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