Defending champion Nadal, fresh from his ninth Italian Open title last weekend, will see first two rounds in the French capital against qualifiers, and a possible third-round encounter with Belgian David Goffin looms ahead as the draw for French Open took place here on Thursday, reports Xinhua news agency.
The Spaniard can expect seventh-seeded Japanese Kei Nishikori or the 12th-seeded Daniil Medvedev of Russia in the last eight.
Federer, in his first appearance at Roland Garros since 2015, will take on Italy's Lorenzo Sonego in the opening round. He has to overcome the Greek talent Stefanos Tsitsipas ahead of highly-anticipated semifinal against Nadal, while the sixth seed should also beware of Stan Wawrinka or Marin Cilic beforehand.
World number one Novak Djokovic, in quest for rare four Grand Slam titles in a row across the year, meets Hubert Hurkacz of Poland before possibly facing American player Sam Querrey in the second round. Denis Shapovalov, Borna Coric, Fabio Fognini and Alexander Zverev will be the Serbian's potential challenger in his quarter.
Also placed in the top half, last year's finalist Dominic Thiem can possibly strive for the last four spot with Juan Martin del Potro.
In the women's category, Naomi Osaka targets at her third straight Grand Slam champion. If things go well in the first round against Anna Karolina Schmiedlova, the world number one would embrace the challenge from either the 2017 Roland Garros champion Jelena Ostapenko or former world number one Victoria Azarenka.
Serena Williams can pose a huge threat to Osaka in the quarterfinals, but the 23-time Grand Slam winner has just played one match on clay after last year's tournament.
The top half also featured the title holder Simona Halep, who might take on Petra Kvitova after making into the last eight.
Second-seeded Karolina Pliskova can expect number five seed Angelique Kerber as a potential quarterfinal opponent.
American veteran Venus Williams and number nine seed Elina Svitolina will fight for a second round spot. Both were drawn in the same quarter with Sloane Stephens and Kiki Bertens.
The 16th-seeded Wang Qiang and Zheng Saisai set up an all-Chinese clash in the first round. The winner would see Halep across the net if she makes her way to the last 16.
Zhang Shuai kicks off her campaign against a qualifier, while Zhu Lin faces Romania's Irina-Camelia Begu.
Wang Yafan, the other Chinese player out of five, plays Marketa Vondrousova and would challenge Kerber if advanced.
( With inputs from IANS )