Schumer and her husband chef Chris Fischer, welcomed their first bundle of joy a son, named Gene in May 2019, but on January 9, the "Trainwreck" actress said they had turned to the alternative method of conception to help increase their chances of having another baby, reports aceshowbiz.com.
Schumer then asked her Instagram followers for any advice about undergoing IVF as she shared a picture of her stomach, which had been bruised from various hormone injections to increase fertility.
She captioned the image: "I'm a week into IVF and feeling really run down and emotional. If anyone went through it and if you have any advice or wouldn't mind sharing your experience with me please do.
"My number is in my bio. We are freezing my eggs and figuring out what to do to give Gene a sibling."
The actress's appeal led to a number of her famous friends and followers to inundating the funnywoman with messages of support.
"I'm praying for you and chris. I'm sorry!" wrote Selena Gomez.
The IVF news comes after the actress endured a rough pregnancy with Gene, suffering from extreme morning sickness condition hyperemesis gravidarum, which forced her to cut short her standup tour after being admitted to hospital in early 2019.
Schumer and Fischer wed in 2018.
( With inputs from IANS )