Sydney, Aug 7 The immune boosting benefits of a tuberculosis vaccine can be seen in infants more than one year after vaccination, according to a new study.
The research, led by the Murdoch Children's Research Institute (MCRI) in Australia, has shown how the BCG vaccine, developed to prevent the risk of tuberculosis, can produce a 'trained immunity response' lasting more than 14 months after the vaccine is administered.
The randomised controlled trial, published in Science Advances, involved 130 infants. Those randomised to be vaccinated received their jab within 10 days of birth.
Murdoch Children's Samantha Bannister said 14 months after having the BCG vaccination they saw reprogramming, a process where genes were switched off or on, in a specific blood cell type, called the monocyte.
"The off-target effects of the BCG vaccine against a range of viruses are explained in part by the reprogramming of how your genes work in the monocyte due to environmental and behavioural factors," she said.
The reprogramming of monocytes, a cell previously thought to have no capacity for memory, leads to trained immunity.
According to Associate Professor Boris Novakovic from the MCRI, the off-target effects were first identified in Africa, where BCG vaccinated children had reduced overall death rates.
"The off-target effects in Africa were known to last more than a year, but previous studies looking at BCG-associated monocyte signatures only looked at one month and three months following vaccination in adults," he said.
For the first time we have shown how the BCG vaccine can have long-lasting effects on the immune system of infants.
"As babies are the main population given the BCG vaccine, this study is important because findings in adults do not always translate to children," Novakovic said.
The team said the next step was to see what impact this early trained immunity offered later in childhood and into adulthood.
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