Fudan, Public university in Shanghai, China

China has approved for trials its first nasal spray vaccine to combat the novel coronavirus. The contagion has claimed over 9,04,000 lives and infected more than 27 million people globally since it first emerged in China last year.China's only nasal spray vaccine against the coronavirus is expected to start phase I clinical trials in November, and it is recruiting 100 volunteers, official media reported on Thursday.It is the only vaccine of its type approved by China's National Medical Products Administration, the state-run Global Times reported. The vaccine is a collaborative mission between Hong Kong and the Chinese mainland that involves researchers from the University of Hong Kong, Xiamen University, and Beijing Wantai Biological Pharmacy.Microbiologist from the University of Hong Kong, Yuen Kwok-yung, said the vaccine stimulates the natural infection pathway of respiratory viruses to activate the immune response.The nasal spray vaccination could generate double protection for vaccine recipients - influenza and the novel coronavirus if it also contains influenza viruses including H1N1, H3N2 and B, Yuen said, adding that it would take at least another year to finish the three clinical trials. A Beijing-based immunologist told the daily that compared with injections, a nasal spray vaccination is easier to administer and would also be easy to mass-produce and distribute as it adopts the mature influenza vaccine production technology.The nasal spray vaccine uses live attenuated influenza vaccine; the other four technical routes China is using to develop the coronavirus vaccines are inactivated vaccines, adenoviral vector-based vaccines, and DNA and mRNA vaccines. The inactivated vaccine is estimated to be the earliest to be in the market, the report said.The immunologist said the new vaccine may not cause systemic side effects, but side effects may occur in the respiratory system such as asthma and shortness of breath.Ideally, scientists do not expect side effects except for minor nasal obstruction or rhinorrhea, Yuen said.It is not yet clear whether immunity generated from nasal spray vaccinations will last longer than for injected vaccines, the report said.

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