Iit Mandi - Latest News Update, Information, Photos & Videos on Iit Mandi at Lokmat Times

The scientists have unravelled the mechanism by which lead salt can promote fat accumulation in the liver.Epidemiological studies have shown that this affects nine to 32 per cent of the Indian population. And the actual number could be higher as the condition often goes undiagnosed.Non-alcoholic fatty liver disease (NAFLD) is a dangerous epidemic of this generation and is a rapidly growing health problem intimately related to the metabolic group of diseases such as obesity and diabetes, among others.It is a condition wherein there is excessive fat accumulation in the liver.While obesity has been known to be the leading cause for NAFLD, recent observations have shown that even thin people can be metabolically 'obese' and have NAFLD.Their research work was performed in collaboration with researchers from the Council of Scientific and Industrial Research (CSIR), Indian Institute of Toxicology Research in Lucknow and School of Chemical and Life Sciences in Jamia Hamdard in New Delhi.This research work has recently been published in a reputed peer-reviewed journal "FEBS Letters".Prosenjit Mondal, Assistant Professor, School of Basic Sciences, IIT Mandi, who has uncovered the pathway by which lead promotes NAFLD, said: "While the connection between lead and fatty liver disease has been known for a while, the actual mechanism by which lead worsens this condition has hitherto remained unknown."NAFLD and most metabolic group of diseases are often caused by the poor regulation of De novo lipogenesis, a complex process in which carbohydrates circulating in the blood are converted into fat.The poor regulation of De novo lipogenesis leads to abnormal production of fat, which settles in the liver and other internal organs as visceral fat.It has been found that the metal lead, which is a serious environmental toxin, can lead to poor regulation of fat formation and deposition in the liver.Lead toxicity is a serious concern in India and the use of lead containing paints, pesticides, packaging and even beer contributes towards high exposure of Ind to this toxic metal and its salts.Lead salts absorbed by the human body is stored in soft tissues, and autopsy studies have shown that the liver hoards almost 33 per cent of the total lead cruising in the body.( With inputs from IANS )

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Pahalgam Terror Attack

Tahawwur Rana

IPL 2025

CM Devendra Fadnavis

Mumbai Local

Weather Update

Iit MandiFOLLOW

Iit mandi, Latest News

Technology :PM reviews 'Made in India' low-cost landslide monitoring system at Mandi

New Delhi/Mandi, Dec 27 Prime Minister Narendra Modi on Monday reviewed the Landslide Monitoring and Early Warning System ... ...

Health :How excess sugar consumption causes fatty liver

Mandi, June 14 A team of researchers from IIT Mandi has identified the underlying biochemical relationship between the ... ...

National :IIT Mandi study reveals structure of NSP1 C-terminal region in isolation, a key protein in Covid-19 virus in host cell environment

Researchers at the Indian Institute of Technology (IIT), Mandi in Himachal Pradesh revealed the structure of 'NSP1 C-terminal region' in isolation, which is a key protein of the Covid-19 virus in a host cell environment. ...

Technology :IIT Mandi researchers develop low-cost smart ventilators

The Indian Institute of Technology Mandi (IIT Mandi) on Thursday said its researchers have developed two low-cost portable ventilators. ... ...

National :IIT Mandi to disburse Rs 10 crore to startups

IIT Mandi Catalyst will now disburse over Rs 10 crore to startups over next five years, it was announced on Tuesday. ...

National :IIT unravels connection of lead toxicity with liver

26 Researchers at the Indian Institute of Technology, Mandi have shown how lead intake promotes accumulation of fat in the liver which can cause obesity. ...