Karolinska Institutet English news | Karolinska Institutet, Latest News & Live Updates in English | English News (Latest English News) at Lokmattimes.com

The new SGLT2 inhibitors, which are now a commonly used drug group, reduce blood glucose, they added.In the study published in the journal The BMJ, the researchers wanted to show if there were positive cardiovascular effects from SGLT2 inhibitors in a broader patient group."There is cardiovascular benefit from SGLT2 inhibitors for a broader patient group in routine clinical care. This is an important result that we believe may be of interest to patients as well as drug authorities and doctors," said study principal investigator Bjorn Pasternak, Associate Professor at the Karolinska Institutet in Sweden.The researchers used several national registries containing data on drug use, diseases, cause of death and other data from close to 21,000 patients with type 2 diabetes who began treatment with SGLT2 inhibitors between April 2013 and December 2016.This information was then compared with an equal size matched population who began treatment with a different diabetes drug DPP4 inhibitor.The primary outcomes in the study were major cardiovascular events defined as myocardial infarction, stroke or cardiovascular death and hospital admission for heart failure. An important secondary outcome was death by any cause.In the primary analysis, the patients were monitored throughout the follow-up period, regardless of whether they had completed their treatment.The researchers found that the use of SGLT2 inhibitors was associated with a reduced risk of heart failure but not with major cardiovascular events.The risk of heart failure was 34 per cent lower in the SGLT2 inhibitor group than in the DPP4 inhibitor group.The use of SGLT2 inhibitors was also linked to a 20 per cent lower risk of death.The results are applicable primarily to dapaglifozin, which was the predominant SGLT2 inhibitor used in Scandinavia during the study period.( With inputs from IANS )

Karolinska InstitutetFOLLOW

Karolinska institutet, Latest News

A team of researchers discovered that use of antibiotics with a greater spectrum of microbial coverage may be associated with an increased risk of new-onset inflammatory bowel disease (IBD) and its subtypes ulcerative colitis and Crohn's disease. ...

Researchers now claim that the risk of some men sexually abusing children can be reduced by a drug that lowers testosterone levels.Researchers at Karolinska Institutet and Gothenburg University in Sweden have now evaluated the effect of a drug called ...

Parents, please take a note. Researchers have found that babies born with low birth weights are more likely to have poor cardiorespiratory fitness later in life than their normal-weight peers. ...

Researchers have developed a method based on artificial intelligence (AI) for diagnosis and grading of prostate cancer. ...

A child born through cesarean procedure or C-section is no more likely to develop obesity than those born through vaginal delivery, new research has found. ...

A mobile app can help manage uncontrolled asthma by measuring lung function and giving feedback in the form of automated and doctor-prescribed treatment recommendation, say researchers. ...

The new type of drugs for type 2 diabetes SGLT2 inhibitors are associated with a reduced risk of heart failure by 34 per cent, researchers said. ...