Peter rudebeck, Researcher

In a recent study, scientists have found that the body-state monitoring neurons can hijack the decision-making process.The findings of the study were published in the journal 'PNAS' (Proceedings of the National Academy of Sciences).Anxiety, addiction, and other psychiatric disorders are often characterised by intense states of what scientists call arousal: The heart races, blood pressure readings rise, breaths shorten, and "bad" decisions are made.In an effort to understand how these states influence the brain's decision-making processes, scientists at the Icahn School of Medicine at Mount Sinai analysed the data from a previous study of non-human primates.They found that two of the brain's decision-making centres contain neurons that may exclusively monitor the body's internal dynamics.Furthermore, a heightened state of arousal appeared to rewire one of the centres by turning some decision-making neurons into internal state monitors."Our results suggest that the brain's decision-making circuits may be wired to constantly monitor and integrate what is happening inside the body," said Peter Rudebeck, PhD, Associate Professor in the Nash Family Department of Neuroscience and Friedman Brain Institute at Mount Sinai and the senior author of the study."Because of that, changes in our level of arousal can alter the way that these circuits work," Dr Rudebeck continued."We hope that these results will help researchers gain a better understanding of the brain areas and fundamental cellular processes that underlie several psychiatric disorders," Dr Rudebeck added.The study was led by Atsushi Fujimoto, MD, PhD, an Instructor in Dr Rudebeck's lab who previously studied how the brain controls risk-taking.For years scientists have described the relationship between arousal and decision-making performance as a "U-shaped curve".Basically, a little bit of arousal -- such as that experienced after a cup of coffee -- might produce peak performance. But too much or too little arousal increases the chances that the brain will make slow or incorrect decisions.Initial results from this study supported this idea. The researchers analysed data from a previous set of experiments that tested the ability of three rhesus monkeys to decide between receiving two rewards: either a lot of tasty juice or a little.Dr Rudebeck performed these experiments while working as a post-doctoral fellow at the National Institute of Mental Health.As expected, the monkeys consistently chose to have more juice, and on average they made this decision faster when their hearts were beating faster, supporting the idea that an aroused state fosters better performance.Next, the researchers analysed the electrical activity recorded from neurons in two of the brain's decision centres called the orbitofrontal cortex and dorsal anterior cingulate cortex.They found that the activity of about a sixth of the neurons in either area correlated with fluctuations in heart rate. In other words, if an animal's heart rate changed, then the activity of these cells would also change by either speeding up or slowing down.This activity appeared to be unaffected by the decisions made about the different rewards that the monkeys were receiving. Meanwhile, the activity of the remaining cells in each area appeared to be primarily involved in the decision-making process."Brain scanning studies have suggested that bodily arousal alters the activity of these decision-making centres. Our results both support this idea on a cellular level and suggest that the sole job of some of these neurons is to track the body's internal, or interoceptive, states," Dr Fujimoto said."The next question we had was: 'What might happen during the type of heightened arousal states seen in patients who suffer from anxiety, addiction, and other psychiatric disorders?'," Dr Fujimoto added.To answer the question, the researchers analysed the data obtained after the amygdala, the brain's emotional centre, was surgically turned off in each animal. This raised heart rates by up to 15 beats per minute.Now, in this higher arousal state, the faster the animals' hearts beat, the slower they were to choose a reward. This suggests that when the animals' arousal state was heightened, it actually hampered the decision-making process.When the team looked at the neural activity, they found something even more interesting.The heightened arousal state appeared to alter the roles that the neurons played during decision-making. In both brain centres, the researchers saw evidence of a decrease in the number of neurons involved in the decision-making process.Moreover, in the dorsal anterior cingulate cortex, the number of neurons that appeared to track internal states rose slightly. This altered the balance of information represented in this area as if the neural signals for decision making were "hijacked" by arousal."Although not definitive, our results suggest that a heightened arousal state degrades and takes control of the decision-making circuits in the brain," Dr Rudebeck said."We plan to continue studying how arousal can influence higher brain functions and how this contributes to psychiatric disorders," Dr Rudebeck concluded.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Pahalgam Terror Attack

Tahawwur Rana

IPL 2025

CM Devendra Fadnavis

Mumbai Local

Weather Update

Peter Rudebeck, NewsFOLLOW

Peter rudebeck, Latest News

Technology :Study finds how a racing heart may alter decision-making brain circuits

In a recent study, scientists have found that the body-state monitoring neurons can hijack the decision-making process. ...