Robert seder, Sam Seder's father

Investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health have reported an experimental therapeutic cancer vaccine induced two distinct and desirable immune system responses that led to significant tumor regression in mice.The researchers found that intravenous (IV) administration of the vaccine boosted the number of cytotoxic T cells capable of infiltrating and attacking tumor cells and engaged the innate immune system by inducing type I interferon.The innate immune response modified the tumor microenvironment, counteracting suppressive forces that otherwise would tamp down T-cell action. Modification of the tumor microenvironment was not seen in mice that received the vaccine via needle injection into the skin (subcutaneous administration).Dubbed "vax-innate" by the scientific team, the approach achieves an important goal in the quest for more effective immunotherapeutic vaccines for cancer. The study demonstrates that IV vaccine delivery enables and enhances T-cell immunity by overcoming tumor-induced immunosuppressive activity.The researchers say the candidate vaccine might also be given intravenously to people who have already received tumor-specific T cells as a therapy. The researchers note that it could also improve tumor control by increasing the number of T cells and altering the tumor microenvironment to make them function better.The experimental vaccine, SNAPvax, was designed by Robert Seder, M.D., and colleagues at the NIAID Vaccine Research Center (VRC) together with collaborators from Vaccitech North America, a clinical-stage biopharmaceutical company in Baltimore, Maryland. Vaccitech announced plans to advance the SNAPvax platform for use in treating human papilloma virus-associated cancer in 2023.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Narendra Modi

Lok Sabha Election 2024

Heatwave In India

Mumbai Water Cut

Maharashtra Lok Sabha Election

IPL 2024

Robert SederFOLLOW

Robert seder, Latest News

Health :Experimental cancer vaccine shows promise in animal trials

Researchers from the National Institute of Allergy and Infectious Diseases (NIAID), have reported that an experimental therapeutic cancer vaccine ... ...

Technology :Researchers find experimental cancer vaccine shows promise in animals

Investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health have ... ...