uk English news | uk, Latest News & Live Updates in English | English News (Latest English News) at Lokmattimes.com

Cambridge [UK], July 11 : Although most individuals don't associate oral disease with serious health issues, growing evidence suggests that oral bacteria play an important role in systemic disorders such as colon cancer and heart disease. New Forsyth Institute research suggests a relationship between periodontal (gum) disease and the production of amyloid plaque, a hallmark of Alzheimer's disease.In their paper, "Microglial cell response to experimental periodontal disease," published in the Journal of Neuroinflammation, Forsyth scientists and their collaborators at Boston University demonstrate that gum disease can lead to changes in brain cells called microglial cells, which are responsible for defending the brain from amyloid plaque. This plaque is a type of protein that is associated with cell death, and cognitive decline in people with Alzheimer's. The study provides important insight into how oral bacteria makes its way to the brain, and the role of neuroinflammation in Alzheimer's disease."We knew from one of our previous studies that inflammation associated with gum disease activates an inflammatory response in the brain," said Dr. Alpdogan Kantarci, senior member of staff at Forsyth and a senior author of the study. "In this study, we were asking the question, can oral bacteria cause a change in the brain cells?"The microglial cells the researchers studied are a type of white blood cell responsible for digesting amyloid plaque. Forsyth scientists found that when exposed to oral bacteria the microglial cells became overstimulated and ate too much. "They basically became obese" Dr. Kantarci said. "They no longer could digest plaque formations."The finding is significant for showing the impact of gum disease on systemic health. Gum disease causes lesions to develop between the gums and teeth. The area of this lesion is the size of your palm. Dr. Kantarci explained, "It's an open wound that allows the bacteria in your mouth to enter your bloodstream and circulate to other parts of your body." These bacteria can pass through the blood/brain barrier and stimulate the microglial cells in your brain.Using mouse oral bacteria to cause gum disease in lab mice, the scientists were able to track periodontal disease progression in mice and confirm that the bacteria had traveled to the brain.They then isolated the brain microglial cells and exposed them to the oral bacteria. This exposure stimulated the microglial cells, activated neuroinflammation and changed how microglial cells dealt with amyloid plaques."Recognizing how oral bacteria causes neuroinflammation will help us to develop much more targeted strategies," said Dr. Kantarci. "This study suggests that in order to prevent neuroinflammation and neurodegeneration, it will be critical to control the oral inflammation associated with periodontal disease. The mouth is part of the body and if you don't take care of oral inflammation and infection, you cannot really prevent systemic diseases, like Alzheimer's, in a reproducible way."This study is the first time that scientists caused periodontal disease with mouse-specific bacteria and could study the effects of same-species oral microbiome on the brain. Having same-species bacteria and cells brings the test closer to replicating what the process looks like in humans.The research team consisted of Rawan Almarhoumi, Carla Alvarez, Theodore Harris, Bruce J. Paster, and Alpdogan Kantarci of Forsyth, and Christina M. Tognoni, Isabel Carreras, and Alpaslan Dedeoglu of Boston University. This study was supported by a grant from the NIH/NIA (R01AG062496) awarded to Drs. Dedeoglu and Kantarci).Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

UkFOLLOW

Uk, Latest News

London, July 12 Several UK health groups on Wednesday accused big pharmaceutical companies of extracting about 11.9-12.6 billion ... ...

Los Angeles, July 12 On his way to the UK to promote his new series 'Special Ops: Lioness', ... ...

London [UK], July 12 : Following his win over Andrey Rublev in the quarterfinal of Wimbledon championship, Serbian tennis ... ...

Nottingham [UK], July 12 : Williams Formula 1 team reveals their new car that will feature in Singapore, Japan ... ...

Sussex [UK], July 12 : English defender Lewis Dunk has signed a new deal until 2026 with Brighton & ... ...

London [UK], July 11 : Serbian tennis legend Novak Djokovic lauded his round-of-16 opponent Hubert Hurkacz for his serving ... ...

Leeds [UK], July 11 : Australia all-rounder Mitchell Marsh returned to the side with an outstanding performance of 118 ... ...

Cambridge [UK], July 11 : Although most individuals don't associate oral disease with serious health issues, growing evidence suggests ... ...