University Of Manchester - Latest News Update, Information, Photos & Videos on University Of Manchester at Lokmat Times

The findings of a new study reveal that patients with lupus are more likely to have metabolic syndrome and insulin resistance, which are both the factors linked to heart disease if they have lower vitamin D levels.An international research team, led by experts at the University of Birmingham and the University of Manchester, studied vitamin D levels in 1,163 SLE patients across 33 centres in 11 countries (UK, USA, Canada, Spain, The Netherlands, Sweden, Iceland, Switzerland, Turkey, South Korea and Mexico), publishing its findings in Rheumatology.Researchers believe that boosting vitamin D levels may improve control of these cardiovascular risk factors, as well as improving long-term outcomes for patients with systemic lupus erythematosus (SLE).Given that photosensitivity is a key feature of SLE, scientists say that a combination of avoiding the sun, using high-factor sunblock, and living in more northerly countries may contribute to lower levels of vitamin D in lupus patients. Patients with more severe diseases also had lower vitamin D levels.Report co-author Dr John A Reynolds, Clinical Senior Lecturer in Rheumatology at the University of Birmingham, commented: "Our results suggest that co-existing physiological abnormalities may contribute to long-term cardiovascular risk early on in SLE."We found a link between lower levels of vitamin D and metabolic syndrome and insulin resistance. Further studies could confirm whether restoring vitamin D levels helps to reduce these cardiovascular risk factors and improve quality of life for patients with lupus."Lupus is an uncommon incurable immune system illness, more common in women, where the immune system is overactive, causing inflammation anywhere in the body. Untreated, the condition threatens irreversible damage to major organs including kidneys, heart, lungs and brain.Metabolic syndrome is a combination of diabetes, high blood pressure (hypertension), abnormal cholesterol levels, and obesity. People with metabolic syndrome are at greater risk of getting coronary heart disease, stroke and other conditions affecting the blood vessels.The researchers note that patients with SLE have an excess cardiovascular risk, up to 50 times that seen in people without the condition - this cannot be attributed to traditional cardiovascular risk factors, such as high blood pressure or smoking, alone.The mechsms underlying the association between high blood pressure and low vitamin D in SLE are not clear, but researchers believe they may be linked to the impact of vitamin D deficiency on the renin-angiotensin hormone system, which regulates blood pressure, fluid, and electrolyte balance, as well as systemic vascular resistance."This is the largest-ever study examining associations between vitamin D levels and metabolic syndrome in SLE; it also has the advantage of being an international cohort with diverse racial and ethnic backgrounds - generating results that will be applicable across many settings," commented Dr. Reynolds.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

University Of ManchesterFOLLOW

University of manchester, Latest News

London, Nov 17 People who tested positive for Covid-19 (confirmed by a PCR test) had an increased risk ... ...

London, Oct 30 A team of researchers has identified a common link between Perrault syndrome, a rare genetic ... ...

Beijing, Oct 8 The first lunar sample in more than 40 years, brought by China's Chang'e-5 probe also ... ...

London, Sep 21 the UK has kicked off a trial of what has been described as the world's ... ...

London, Sep 21 Another 36,100 people in Britain have tested positive for Covid-19, bringing the total number of ... ...

London, Sep 14 Planning to build a house on Mars may now be easy as scientists have created ... ...

The increasingly competitive Real Money Gaming Industry in India - among the fastest-growing globally - has witnessed a fair number of deals and investment activity, especially over the last year. ...

The findings of a new study reveal that patients with lupus are more likely to have metabolic syndrome and insulin resistance, which are both the factors linked to heart disease if they have lower vitamin D levels. ...