Among the detained students were Delhi University Students Union President Akshit Dhaiya, and ABVP's state Secretary Siddharth Yadav.
Delhi Police had imposed prohibitory orders in the area and put up triple layer of barricades. Some protesters, however, climbed over the barricades and scuffled with the security personnel, who comprised CRPF personnel along with Delhi Police.
The protesters raised slogans against the JNU administration and the HRD Ministry who, according to students, had unilaterally imposed fee hike on the students.
Earlier, the ABVP demanded resignation of Human Resource Development Minister, Ramesh Pokhriyal 'Nishank'.
Slogans like "HRD Minister istifa do (HRD minister resign)", "Fee hike nahi sahenge," (We won't tolerate a fee hike)," echoed opposite the Parliament Street police street as agitating student clambered on to the barricades.
"First of all, we are not the student wing of BJP, and we have always stood for students no matter which party leads the government," Siddharth Yadav said during the march from Mandi House to the HRD Ministry.
"We are here to stand for students' right and we demand resignation of HRD Minister Ramesh Pokhriyal on this issue," he added.
Students of the Jawaharlal Nehru University (JNU) have been protesting for the past several days demanding a complete rollback of a proposed hike in hostel fees, along with reconvening of the Inter-Hall Administration meeting that had passed the proposed fee hike on October 28.
The JNU Students Union (JNUSU) also demanded the resignation of Vice Chancellor Mamidala Jagadesh Kumar, claiming he had lost the faith of students and the teachers.
( With inputs from IANS )