Andrea meredith, Researcher

A new study has found that a common medication used for attention deficit hyperactivity disorder (ADHD) appears to help manage the symptoms of a rare and currently difficult to treat genetic movement disorder primarily found in children.The study has been published in the 'Movement Disorders Clinical Practice Journal'.The disorder, KCNMA1-linked channelopathy, named after the affected gene, can cause abnormal, involuntary movements from collapsing episodes, in which patients slump forward with their arms and legs appearing rigid. These episodes can occur up to 300 times per day, putting patients at risk of serious injury.The researcher found that the stimulant drug, lisdexamfetamine, reduced these attacks and may help other accompanying symptoms, such as seizures and developmental delays, as well.The researchers said that their findings can help to better understand different brain regions involved with the attacks and how the disease manifests itself. While this research shows promise of specifically treating KCNMA1-linked channelopathy, there are broader implications to exploring the treatment effects on the body, potentially shedding light on the mechanisms behind other neuromuscular diseases and how to treat them."Sometimes the science doesn't initially lead us to the answers, it is often the patients and families themselves," said senior author Dr Andrea Meredith, Professor of Physiology at the University of Maryland School of Medicine.Only about 75 people so far have been identified worldwide with this disorder which was identified as recently as 2005. A major advance came in 2019 when it was reported anecdotally that a child suffering from the disorder was prescribed lisdexamfetamine by their neurologist, which according to the family seemed to help. The physician tried this stimulant medication, commonly used to treat cataplexy-related disorders; the child's symptoms resembled cataplexy, which is a sudden muscle weakness without losing consciousness.From there, word spread to other families over social media, news media, and the disease's advocacy foundation, KCNMA1 Channelopathy International Advocacy Foundation, which was co-founded by Dr Meredith. The buzz from the patients' families spurred neurologists, including the study authors, to test the relatively safe drug that is approved by the U.S. Food and Drug Administration to treat ADHD.For their study, the researchers analyzed reports of six patients treated with lisdexamfetamine. They found that the collapsing episodes were reduced by about 10-fold or were completely resolved in four patients. Most patients also showed improvements in speech, school performance, concentration, and social skills, all of which can affect patients with this disease as well. None of the patients experienced seizures during the study period. The most common side effect reported as a loss of appetite and difficulty sleeping."From the anecdotal reports we already had, we weren't particularly surprised by these findings," said Dr Meredith."But gathering the real-world evidence that the drug is actually working to treat the symptoms is important for clinicians who may prescribe the drug to officially diagnosed patients," she added.It is currently unclear how lisdexamfetamine works to treat the attacks. The gene affected in the disorder, KCNMA1, encodes a protein that makes a 'channel' in brain and muscle cells. This channel lets potassium out of the cell to change its electric charge. Neurons in the brain send messages and tell the muscles to move using these electrical signals, but the exact way this channel disruption leads to the symptoms experienced by the patients is unknown.However, the success of lisdexamfetamine treatment in a small group of patients may provide the answers."We have exciting mechanistic avenues to pursue as a result of this finding. We do know that the drug does not directly affect the activity of the channels, so we think the drug has either a separate or an indirect effect, on the channels," said Dr Meredith.The researchers plan to continue studies of the disorder and the drug in their mouse models."Rare diseases are often overlooked in research and treatment," said E. Albert Reece, MD, PhD, MBA, Executive Vice President for Medical Affairs, UM Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine."We are proud of our researchers in pursuing treatment of a rare disease that opens new doors, pushes medical boundaries, and improves the lives of those who may feel left behind," Reece added.Other authors on the study included Sotirios Keros, MD, PhD, and Zach Grinspan, MD, MS, of Weill Cornell Medical College; Jennifer Heim, MD, Wejdan Hakami, and Michael Kruer, MD, of Phoenix Children's Hospital; and Efrat Zohar-Dayan and Bruria Ben-Zeev, MD, of Chaim Sheba Medical Center, Israel.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Narendra Modi

Lok Sabha Election 2024

Heatwave In India

Mumbai Mega Block

Maharashtra Lok Sabha Election

T20 World Cup 2024

Andrea MeredithFOLLOW

Andrea meredith, Latest News

Technology :Study finds ADHD drugs may treat symptoms of genetic movement disorder in kids

A new study has found that a common medication used for attention deficit hyperactivity disorder (ADHD) appears to help manage the symptoms of a rare and currently difficult to treat genetic movement disorder primarily found in children. ...