Cedars-sinai medical center, Hospital in Los Angeles, California

A collaborative team of neuroscientists have identified different sets of individual neurons that are responsible for memory-based decision-making.The study was led by neuroscientists from Caltech and Cedars-Sinai Medical Center in Los Angeles, and the results are published in the journal Science."An essential aspect of cognitive flexibility is our ability to selectively search for information in memory when we need it," said senior author Ueli Rutishauser, visiting associate in biology and bioengineering at Caltech and Board of Governors Professor in Neurosciences at Cedars-Sinai Medical Center."This is the first time neurons have been described in the human brain that signal memory-based decisions. In addition, our study shows how memories are transferred to the frontal lobe selectively and only when needed," Rutishauser added.The study, which has implications for the treatment of memory problems associated with Alzheimer's disease, epilepsy, and schizophrenia, was performed in patients who were already undergoing brain surgery for the treatment of their seizures.The volunteers viewed images on a screen and answered different types of questions about the images, while the researchers recorded the activity of individual neurons in their brains using implanted electrodes.For example, a subject might be shown a picture of somebody they had never seen before and asked, "Have you seen this face before?" or "Is this a face?" The two questions, respectively, help the researchers distinguish between a memory-based decision and a decision based not on memories but categories, such as faces."We make decisions based on retrieved memories all the time," said lead author Juri Minxha, a postdoctoral scholar at Cedars Sinai and visitor in neuroscience at Caltech."'Which restaurant should I order food from tonight?' or 'Where should I look next for my keys?' In this study, we asked simple yes or no questions designed to cause a volunteer to access either their recent memory or their categorical knowledge," the author added.The encoding and retrieval of memories occur in the lower-middle portion of the brain in a region called the medial temporal lobe, which includes the hippocampus. Decision-making processes involve a region at the front of the brain called the medial frontal cortex."The ability to flexibly engage and utilize our memories to make decisions depends on interactions between the frontal and temporal lobes, the former being the site of executive control and the latter being where memories of this kind are stored. Little was known before about how the interactions between these two parts of the human brain occur," said Rutishauser.In the study, the researchers monitored single neurons in both the temporal lobe and the frontal lobe of 13 subjects. The results revealed neurons that encode memories in the temporal lobe, and "memory choice neurons" in the frontal lobe; these neurons do not store memories but rather help retrieve them."Both the medial temporal lobe and medial frontal cortex become active when the decision requires that the patient remember something. The interaction between these two brain structures allows for successful memory retrieval," said Minxha."So if we ask a patient if they have seen a face before, neurons in both regions become active. But if we show them the same image and ask, "Is this a face?" then the memory choice neurons remain silent. Instead, we see a second distinct population of neurons in the frontal lobe, supporting the subject's current goal of categorizing the image," Minxha added.The study also identified a different set of "context neurons" in the frontal lobe. These neurons encode information about the instructions given to a subject for a given task. For example, the subjects were told to either press a button or to use eye movements to relay their answer to a question; the context neurons signaled which of these two actions to take, independent of what the answer to the question was."Interestingly, we found that the decision was represented by the memory choice neurons in an abstract way, such that the very same neurons could signal this information in different contexts. This likely accounts for much of the flexibility that we see in human decision-making," said Ralph Adolphs, Caltech's Bren Professor of Psychology, Neuroscience, and Biology; Director of the Caltech Brain Imaging Center; and an affiliated faculty member of the Tianqiao and Chrissy Chen Institute for Neuroscience at Caltech.Communication between the temporal and frontal lobes was also observed by analyzing theta waves, which are common in the temporal lobe. The researchers found that neurons in the frontal lobe selectively aligned their activity with theta waves in the temporal lobe only when subjects made a memory-based decision.The researchers say they could even tell if a subject was going to correctly identify a face simply based on how strongly the memory choice neurons in the frontal lobes coordinated their activity with theta waves in the temporal lobe.According to Adolphs, this study led by the team, when taken together, reveals many key "building blocks" that make human cognition so flexible.( With inputs from ANI )

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