Uni, School category

New York, Nov 14 Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, finds a new research.The study, completed in an animal model, found that excessive inflammation resulting from obesity raises the number of myeloid-derived suppressor cells (MDSC), a group of immune cells that increase during illness to regulate immune function.MDSCs, which originate in the bone marrow, develop into a range of different cell types, including osteoclasts (a cell that breaks down bone tissue)."This research promotes the concept that MDSC expansion during obesity to become osteoclasts during periodontitis is tied to increased alveolar bone destruction," said researcher K.H. Kwack from the University at Buffalo."Taken together, this data supports the view that obesity raises the risk of periodontal bone loss," Kwack added.Bone loss is a major symptom of gum disease and may ultimately lead to tooth loss.Also known as periodontal disease, gum disease affects more than 47 per cent of adults 30 years and older, according to the Centers for Disease Control and Prevention.For the study, published in the Journal of Dental Research, the team examined two groups of mice fed vastly different diets over 16 weeks one group, a low-fat diet that derived 10 per cent of energy from fat, the other group a high-fat diet that drew 45 per cent of energy from fat.The investigation found that the high-fat diet group experienced obesity, more inflammation and a greater increase of MDSCs in the bone marrow and spleen compared to the low-fat diet group.The high-fat diet group also developed a significantly larger number of osteoclasts and lost more alveolar bone (the bone that holds teeth in place).Also, the expression of 27 genes tied to osteoclast formation were significantly elevated in the group fed a high-fat diet.Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

UniFOLLOW

Uni, Latest News

Dhaka, Dec 7 Braving day-long incessant rain, around 2,000 pro-liberation campaigners on Tuesday held rallies across Bangladesh, marking ... ...

Aurangabad, Dec 6: Tributes were paid to Dr Babasaheb Ambedkar on his Mahaparinirvan Din (death anniversary) through various places ... ...

Aurangabad, Dec 5: Various programmes have been organised in the city to pay tributes to Dr Babasaheb Ambedkar on ... ...

To regulate the movement of outsiders, Osmania University in Hyderabad is charging Rs 200 monthly from morning walkers, said vice-chancellor D Ravinder. ...

Santosh (deemed to be) University hosted Aarogyam, a research and innovation initiative to identify young minds inclined towards research. Through this initiative, the institution held a series of research competitions on November 11, 2021. The inten ...

Chennai, Dec 1 Experts have warned of a dengue outbreak in Chennai and surrounding areas as the mosquito ... ...

Aurangabad, Nov 20: Members of State Colleges and University non-teaching Employees union agitated in front of the administrative building ... ...

New York, Nov 14 Chronic inflammation caused by obesity may trigger the development of cells that break down ... ...