Earlier this month, Scorsese denounced the Marvel movies, saying that these were "not cinema". He likened them to "theme parks". Coppola described the films as "despicable".
At a Wall Street Journal event, Iger hit back at the accomplished filmmakers, calling them disrespectful, reports independent.co.uk.
He said that if they "want to bitch about movies, that's certainly their right" but they clearly "don't see how the audience is reacting to them".
"Francis Ford Coppola and Martin Scorsese are two people I hold in the highest regard, but when Francis uses the words, 'Those films are despicable', I reserve the word 'despicable' to someone who committed mass murder. These are movies," Iger said.
Iger also pointed out that people are watching Marvel films "by the millions".
"It seems so disrespectful to all the people that work on those films. Are you telling me Ryan Coogler making 'Black Panther' is doing something that is somehow 'less than' what Marty Scorsese or Francis Ford Coppola have ever done on any one of their movies? Like, come on. There. I said it," he added.
Director Ken Loach joined the debate and said the films have "nothing to do with the art of cinema".
( With inputs from IANS )