Washington [US], September 3 : Significant links between the gut microbiome and infant eczema have recently been found, laying the framework for future eczema prevention and therapy through gut microbiota management.
The results of the study were published in the American Society for Microbiology journal mSystems.
“The problem of eczema is increasing, and our study shows it could be a result of unwanted changes in the gut bacterial content. The first year of life could be a critical period to restore the gut bacteria to a more desirable composition,” said the study’s principal investigator Paul Chan, M.D., professor of microbiology at The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Dr Chan and colleagues invited pregnant women who were close to term to participate in the new trial. They gathered data on their health, lifestyle, and events throughout pregnancy and delivery. The researchers visited the women after their babies were born and collected information about their diet, health, and medicines. The researchers set up follow-up clinics to check on the newborns' health and any eczema issues. The researchers sequenced 713 stool samples collected at nine time periods from birth to three years of age to characterise the development and determinants of the gut microbiome in a cohort of 112 term Chinese children.
The researchers revealed alterations in the composition and alpha and beta diversity of the gut microbiota across the first 3 years of life. They identified mode of delivery, feeding mode and intrapartum antibiotics as the major determinants of the early-life gut microbiome, the effects of all of which persisted up to 12 months.
Importantly, by conducting a nested case-control study, they showed that alterations in the infant gut microbiota precede the development of eczema. Interestingly, they identified a depletion of Bacteroides and an enrichment of Clostridium sensu stricto 1 in the gut microbiome of infants with eczema at 1 year old. The same patterns were also observed in C-section born infants within the same time frames, suggesting a role of the gut microbiota in previously reported associations between C-section and increased risk of eczema.
“Our study found that the gut bacterial content of babies changes drastically over the first 3 years of life,” said Dr. Chan. “The mode of delivery and feeding, and the use of antibiotics around the time of delivery affects the gut bacterial content. We observed characteristic changes in the gut bacterial content before the babies present with eczema. Remarkably, those bacterial changes were also observed in babies delivered by C-section. Nevertheless, the link between C-section and eczema requires further studies to verify. Gut bacteria may play a role in preventing or treating eczema.”
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