Study finds sleep apnea during pregnancy may lead to risk of autism-like changes in male offspring

A recent study has found that sleep apnea during pregnancy may increase the risk for brain and behavioural changes linked to autism in the male offspring.

The research has been published in the 'PLOS Biology Journal'.

The findings supported evidence in humans of a link between sleep apnea and neurodevelopmental disorders and provided a potential mechanism to explain the link.

During episodes of sleep apnea, breathing is partially or completely interrupted, often hundreds of timers per night, causing intermittent hypoxia, or decreased blood oxygenation. The incidence of sleep apnea during pregnancy is on the rise, in line with the obesity epidemic, and occurs in about 15 per cent of uncomplicated pregnancies and more than 60 per cent of high-risk pregnancies by the third trimester.

Sleep apnea during pregnancy is known to have detrimental effects on the newborn, but the impacts on neurodevelopment have not been well studied.

To investigate such impacts, the authors, Amanda Vanderplow, Michael Cahill, and colleagues at the University of Wisconsin-Madison subjected pregnant rats to intermittent low oxygen levels during times of rest, during the second half of their gestational period.

The treatment induced hypoxia in the mothers, but (as expected) not in the fetuses. Behavioural abnormalities in the offspring were observed beginning shortly after birth, including altered distress vocalization patterns in both males and females.

Maternal hypoxia also impaired cognitive and social function in male, but not female, offspring, both of which persisted into adulthood. Effects included a reduction in working memory and longer-term memory storage, and reduced interest in socially novel situations.

These behavioural changes were accompanied by significant abnormalities in the density and morphology of dendritic spines, the outgrowths on neurons that receive and integrate signals from other neurons.

In adolescents of both sexes, but much more so in males, the density of dendritic spines was elevated compared to age-matched control animals, an increase due mainly to lack of spine "pruning," or reduction, a process that begins in childhood and is critical for normal brain development. How maternal hypoxia-induced these changes in fetuses, not themselves experiencing hypoxia remains unclear.

The authors found that affected offspring had an excessive activity of a cell signalling pathway known as the mTOR pathway, a feature identified in the cortex of humans with autism and that treatment with rapamycin, an mTOR inhibitor, partially mitigated the behavioural effects of maternal hypoxia in the offspring.

"To our knowledge, this is the first direct demonstration of the effects of maternal intermittent hypoxia during gestation on the cognitive and behavioural phenotypes of offspring," Cahill said.

"Our data provide clear evidence that maternal sleep apnea may be an important risk factor for the development of neurodevelopmental disorders, particularly in male offspring," Cahill continued.

Cahill added, "Based on clinical correlations, maternal sleep apnea during pregnancy has been theorized to potentially increase the risk for autism diagnosis in her offspring; however, functional studies are lacking. Here we show that sleep apnea during gestation produces neuronal and behavioural phenotypes in rodent offspring that closely resemble autism, and demonstrate the efficacy of a pharmacological approach in fully reversing the observed behavioural impairments."

( With inputs from ANI )

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