Munich [Germany], April 13 : T cells, a key element of the immune system, are crucial in preventing viral infections. Extracellular vesicles are shown to be crucial in the activation of these cells in a mouse model by a team led by Prof. Thomas Brocker and Jan Krch from the LMU Biomedical Center.
The findings of the study were published in the journal Proceedings of the National Academy of Sciences.
Extracellular vesicles are tiny membrane particles that are secreted by cells and play a role in cell-to-cell communication. Using a newly developed method, the scientists were able to show that already activated killer T cells - a subcategory of T cells which directly attack diseased cells - engage intensively with these vesicles. This gives the T cells an extra activating "boost," which has the effect of promoting their proliferation and increases activation of various genes that are needed to combat the infection.
Another unexpected finding of the study was that the number of vesicles in the serum decreased after infection, whereas their number increased on T cells in the spleen. From this, the authors concluded that the binding of vesicles to cells is enhanced after an infection. "Extracellular vesicles essentially function as a 'danger signal' for T cells, indicating that the infection has not yet been eliminated," said Krch. "We hope to be able to use this discovery in future for therapeutic approaches aimed at strengthening the T cell response to viruses and tumors."
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