Asian Development Bank English news | Asian Development Bank, Latest News & Live Updates in English | English News (Latest English News) at Lokmattimes.com

England [UK], June 14 : A recent study in the Oxford University Press journal Molecular Biology and Evolution demonstrates that the Neandertal component of Dupuytren's illness is present. Researchers have long known that people of Northern European descent had the disease significantly more frequently than those with African heritage did.Dupuytren's disease is a disorder affecting the hand. Those who suffer from the condition eventually see their hands become bent permanently in a flexed position. Although the condition can affect any finger, the ring and middle fingers are most often afflicted. Scientists have previously identified several risk factors for the condition, including age, alcohol consumption, diabetes, and genetic predisposition. A 1999 Danish study reported 80% heritability for the condition, indicating a strong genetic influence. The condition is much more common in people of Northern European ancestry. One study estimated the prevalence of Dupuytren's disease among Norwegians over 60 years to be as much as 30%. The condition is rare, however, for those of primarily African descent. This apparent geographic distribution has given Dupuytren's disease the nickname "Viking disease."There are geographical differences in the extent of genetic ancestry linking present-day humans to now-extinct groups. People from Africa south of the Sahara have little ancestry from Neandertals or Denisovans, who that lived in Europe and Asia until at least 42,000 years ago. In contrast, people with roots outside of Africa inherited as much as 2% of their genome from Neandertals and some populations in Asia today have up to 5% Denisovan ancestry. Given these regional differences, archaic gene variants can contribute to characteristics or diseases found primarily in certain populations.Given the prevalence of Dupuytren's disease among Europeans, researchers here investigated its genetic origins. They used data from 7,871 cases and 645,880 controls from the UK Biobank, the FinnGen R7 collection, and the Michigan Genomics Initiative to identify genetic risk variants for Dupuytren's disease. They found 61 genome-wide significant variants associated with Dupuytren's disease. Further analysis showed that three of these variants are of Neandertal origin, including the second and third most strongly associated ones. The finding that two of the most important genetic risk factors for Dupuytren's disease are of Neandertal origin leads the scientists to conclude that Neandertal ancestry is a significant factor in explaining the prevalence of the disease in Europe today."This is a case where the meeting with Neanderthals has affected who suffers from illness," said the paper's lead author, Hugo Zeberg, "although we should not exaggerate the connection between Neanderthals and Vikings."Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Asian Development BankFOLLOW

Asian development bank, Latest News

Manila [Philippines], June 15 : The Asian Development Bank (ADB) has approved a USD 100 million concessional loan for ... ...

Lhasa [Tibet], June 15 : China has made the Mandarin language compulsory for the Tibetan students who took China's ... ...

Paris [France], June 15 : G20 Digital Innovation Alliance under India's G20 presidency has been showcased at the ongoing ... ...

Shimla (Himachal Pradesh) [India], June 15 : Himachal Pradesh Chief Minister Thakur Sukhwinder Singh Sukhu, while administering a meeting ... ...

PRNewswire Bangalore (Karnataka) [India], June 15: A lack of access to an office space is the main driver of ... ...

Bhubaneswar (Odisha) [India], June 14 : Former Indian Super League (ISL) League Shield and title-winning head coach Sergio Lobera ... ...

New Delhi [India], June 14 : India will soon overtake China as the largest driver of global oil demand, ... ...

England [UK], June 14 : A recent study in the Oxford University Press journal Molecular Biology and Evolution demonstrates ... ...