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Focusing on clinical trials of atezolizumab, a common immunotherapy treatment for non-small-cell lung cancer (NSCLC), the researchers from Flinders University found improved responsiveness to the drug in those with a high body mass index (BMI)."This is an interesting outcome and it raises the potential to investigate further with other cancers and other anti-cancer drugs," said study lead investigator Ganessan Kichenadasse from the Flinders University in Australia."We need to do further studies into the possible link between BMI and related inflammation, which might help to understand the mechanisms behind paradoxical response to this form of cancer treatment," Kichenadasse said.The WHO estimates at least 2.8 million people die each year as a result of being overweight or obese.Overweight and obesity leads to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance.Risks of coronary heart disease, ischemic stroke and type 2 diabetes mellitus increase steadily with increasing body mass index (BMI), a measure of weight relative to height."Previous studies have explored a concept called as 'obesity paradox' where obesity is associated with increased risks for developing certain cancers and, counter-intuitively, may protect and give greater survival benefits in certain individuals," Kichenadasse said."Our study provides new evidence to support the hypothesis that high BMI and obesity may be associated with response to immunotherapy," Kichenadasse added.For the findings, published in the journal JAMA Oncology, 1,434 participants took part in the study, in which 49 per cent were normal weight, 34 per cent were overweight and seven per cent were obese.The researchers found NSCLC patients with high BMI (BMI 25 kg/m2) in four clinical trials had a significant reduction in mortality with atezolizumab, apparently benefiting from immune checkpoint inhibitor (ICI) therapy.Treatment options for this form of lung cancer are rapidly evolving and includes ICIs, molecular targeted drugs and chemotherapies, the study said."While our study only looked at baseline and during treatment, we believe it warrants more studies into the potentially protective role of high BMI in other cancer treatments," Kichenadasse said.( With inputs from IANS )

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