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Washington [US], June 22 : In low- and middle-income nations where the disease kills more than 3,00,000 women annually, Rice University bioengineers have demonstrated a low-cost, point-of-care DNA test for HPV infections that may make cervical cancer screening more accessible.Almost everyone contracts the HPV virus at some point in their lives, frequently causing no symptoms. However, more than a dozen different forms of HPV can result in persistent infections that lead to cervical cancer, which can be prevented and treated if it is found early and treated properly.It took nine engineers from Rebecca Richards-Kortum's lab at Rice more than two years to create a DNA testing platform that combines the two technologies of isothermal DNA amplification and lateral flow detection in a way that greatly reduces the testing's equipment requirements and procedures. Richards-Kortum's group and co-authors from the National Cancer Institute, the Mozambique Ministry of Health, Baylor College of Medicine, and the University of Texas MD Anderson Cancer Centre demonstrated the platform's ability to produce clinically relevant results on samples collected at both U.S. clinical sites and clinical field sites in Mozambique in a study published this week in Science Translational Medicine."We know what we need to do to prevent cervical cancer," said study first author Kathryn Kundrod, a cancer prevention fellow at the National Cancer Institute and senior advisor for cancer moonshot policy coordination at the White House Office of Science and Technology Policy. "It's really a matter of access at this point, and that's one reason this study is exciting from a global health perspective. It demonstrates a testing process that could potentially be combined with point-of-care diagnostic and treatment technologies to allow women who've never had access to be screened and treated in a single visit in settings like a small clinic or a mobile diagnostic van."In the study, the researchers showed their six-step test for HPV16 and HPV18 two types that account for about 70% per cent of cervical cancer delivered results in 45 minutes and required just two pieces of equipment. One, a small centrifuge, is widely available for about USD 500. The other, a purpose-built, dual-chamber heater called NATflow, allowed the researchers to use disposable cartridges to avoid false positives arising from workspace contamination, a major challenge for point-of-care molecular testing."The vast majority of disease detected through screening is precancerous, before the point at which people have cancer," said Richards-Kortum, Rice's Malcolm Gillis University Professor, professor of bioengineering and the founding director of the Rice360 Institute for Global Health Technologies. "That's why screening programs are so effective. People who are routinely screened very rarely progress to cervical cancer. It's people who have never been screened in their lives, or who get screened on really infrequent intervals, who are really at risk. That's why it's so critical to address the disparities that exist and think about new ways to deliver screening, diagnosis and treatment."Kundrod, who received her Ph.D. from Rice in 2020, is a former student and postdoctoral researcher in Richards-Kortum's lab who led the day-to-day development of the HPV test and the co-development of the platform in conjunction with NATflow manufacturer Axxin of Victoria, Australia. Kundrod said that if both the NATflow platform and test cartridges were produced on a large scale, each dual-chamber heater would cost an estimated $500 and each test less than $5."The platform is the other thing that makes this exciting, because it can easily be adapted for DNA tests for other diseases," she said. "Preventing contamination has been a huge problem for DNA-based point-of-care tests. This is one of the first platforms to address that, and so far it's the only one to solve that in a way where all the pieces can be easily manufactured with injection molding, which is important from a cost perspective."Kundrod said the Rice team's HPV test won't be ready for widespread use until researchers modify it to detect more cancer-causing types of HPV and conduct additional clinical tests. She said studies have consistently shown that HPV screening is the most effective way to prevent cervical cancer and DNA testing is the most effective way to screen for HPV infections."We're grateful to the whole team who made this work possible and are committed to continued development and scale in places where cervical cancer screening is most needed," Richards-Kortum said.Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

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