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A recent study has found that the brains of a small sample of patients who died of COVID-19 displayed some of the same molecular changes found in the brains of people with Alzheimer's disease.The study has been published in the 'Alzheimer's & Dementia: The Journal of the Alzheimer's Association'.The findings could help explain the memory problems reported by sufferers of "long COVID," though the researchers cautioned that the study is small--with data from only 10 patients--and needs to be replicated by others.Early reports of "brain fog" and persistent cardiac symptoms in COVID survivors prompted the Columbia researchers to investigate how certain molecules called ryanodine receptors were affected in this new disease.Defective ryanodine receptors have been implicated in diverse pathogenic processes, ranging from heart and lung disease to the brain's response to stress and Alzheimer's disease, as reported in research led by Andrew Marks, MD, chair of the Department of Physiology & Cellular Biophysics at the Vagelos College of Physicians and Surgeons, who led the new study."When the COVID pandemic hit, like everybody else I was interested in being helpful and doing what we could do," said Marks."What we found is really I think quite unexpected: Not only did we find defective ryanodine receptors in the hearts and lungs of deceased COVID patients, we also found them in their brains," he added.Inside neurons, defective ryanodine receptors have previously been linked to an increase in phosphorylated tau, a well-known hallmark of Alzheimer's.In the new study, the Columbia researchers found high levels of phosphorylated tau in the brains of the COVID patients in addition to defective ryanodine receptors.Phosphorylated tau was found in areas where tau is typically located in Alzheimer's patients, as well as in areas where tau is not typically located in Alzheimer's patients. That suggested that phosphorylated tau in the COVID patients could be a sign of early-stage Alzheimer's and also contribute to other neurological symptoms observed in COVID-19 patients.Increased levels of phosphorylated tau in the brain are believed to be linked to memory problems in Alzheimer's and could be causing similar issues in people with long COVID, Marks said.Based on the findings, together with additional changes found in the brain, the investigators theorized that the immune response characteristic of severe COVID causes inflammation in the brain, which in turn leads to dysfunctional ryanodine receptors and then increases in phosphorylated tau. No changes in the pathways that lead to the formation of amyloid-beta--another hallmark of Alzheimer's--was found."One interpretation of these findings is that long COVID could be an atypical form of Alzheimer's and/or that patients who had severe COVID could be predisposed to developing Alzheimer's later in life, but much more research needs to be done before we can make more definitive conclusions," said Marks.If the memory and neurological problems of long COVID can be traced to defective ryanodine receptors, a drug under development by Marks may help. The drug is now in early clinical trials to treat a muscle disease caused by an inherited defect in the ryanodine receptor. The drug was able to fix the ryanodine defect when applied to the COVID patients' brain tissue."My greatest hope is that other laboratories will look into our findings, and if they are validated, generate interest in a clinical trial for long COVID," said Marks.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

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Department Of Physiology & Cellular Biophysics, NewsFOLLOW

Department of physiology & cellular biophysics, Latest News

Technology :Study finds Alzheimer's-like changes in some COVID patients' brains

A recent study has found that the brains of a small sample of patients who died of COVID-19 displayed some of the same molecular changes found in the brains of people with Alzheimer's disease. ...