Gothenburg university nystrom - Latest News Update, Information, Photos & Videos on Gothenburg university nystrom at Lokmat Times

Washington [US], July 3 : Protein aggregates build up with age and have been linked to neurological illnesses such as Alzheimer's, Parkinson's, and Huntington's disease. A recent work from the Gothenburg University Nystrom lab, in conjunction with the Max Planck Institute for Biology of Ageing in Germany, offers a novel, designed technique that allows protein aggregation to be spatially manipulated in both budding yeast and human cells.Many neurodegenerative diseases like Alzheimer's, Parkinson's or Huntington's disease are associated with the aggregation of misfolded proteins but whether or not these aggregates contribute to these diseases is not clear.The research group of Professor Thomas Nystrom from Gothenburg University was able to export such protein aggregates from cells in an engineered manner, which was published in the journal Nature Communications. The system was first developed in the widely-used model organism, budding yeast, but was extended also for use in human cells.Free of protein aggregatesThe authors achieved this synthetic cellular export system by fusing an aggregate-binding protein to a daughter-cell-targeting factor such that when the daughter cell is pinched off, the mother cell is free of protein aggregates. This approach was effective in dealing with endogenous, age-associated protein aggregates, as well as with mutant Huntingtin aggregates associated with the Huntington's disease.Using this daughter targeting system, they showed that the export of mutant Huntingtin protected yeast mother cells from cell death suggesting that large Huntingtin aggregates may be highly toxic and contribute to the disease, a trait that has been widely debated.Potential future therapy"To our knowledge this is the first demonstration that protein aggregates can be exported from cells in a controlled, engineered manner. Other kinds of cellular damage might be also exported from cells with adapted versions of our targeting system", says Dr. Arthur Fischbach, postdoc and the lead author of the study."Although we currently lack supporting data, there is a possibility that the ATS concept could be employed in the future as a potential novel therapeutic approach for neurodegenerative diseases or at least for gaining a better understanding of them. Given the urgency, there is a strong demand for innovative therapies in this area", he concludes.Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Narendra Modi

Lok Sabha Election 2024

Heatwave In India

Mumbai Water Cut

Maharashtra Lok Sabha Election

IPL 2024

Gothenburg University NystromFOLLOW

Gothenburg university nystrom, Latest News

Technology :Study shows engineered method for removing protein clumps from cells

Washington [US], July 3 : Protein aggregates build up with age and have been linked to neurological illnesses such ... ...