Krishnaswamy kasturirangan, Chancellor of Jawaharlal Nehru University, Delhi

Washington DC [US], September 1 : Researchers have uncovered some novel and unexpected ways that influenza virus and viral RNA are detected by human lung cells, which may have therapeutic ramifications.The annual epidemics that threaten between 3 and 5 million people with severe sickness and result in 290,000 to 650,000 fatalities globally are brought on by influenza viruses, which continue to be a serious threat to human health. These viruses can also cause severe symptoms in young, old, and immunocompromised populations.When these viruses multiply, they predominantly target respiratory epithelial cells, where they harm and kill the cells.Scientists now understand that these epithelial cells play a crucial role in triggering the immune system's antiviral response and are not just passive barriers that are defenceless against attack.The team discovered that viral RNA and influenza viruses stimulate two different molecular pathways in which specific proteins set off chain reactions that result in two proteins called “gasdermin D” and “gasdermin E” being processed in such a way that they form membrane pores in the epithelial cells. These pores allow the release of special agent “cytokines” charged with sparking the immune system into life and also causing the death of the cells which prevents the virus from spreading.To assess the importance of this finding, the team suppressed the formation of the gasdermin pores to see what would happen, and this resulted in increased replication of influenza viruses, underlining how important these gasdermins are in the antiviral response.The research has just been published in the journal iScience. Speaking about the research and its implications, Professor Bowie, who is based in Trinity’s Biomedical Sciences Institute, said, “By forming an EU-wide network of scientists with different expertise in immunology and virology, we were able to ask some fundamental questions about how our bodies respond to RNA viruses such as influenza and SARS-CoV-2. “We realised that very little was known about the initial response to viruses in those early moments when our lungs first encounter a virus. Through Coralie’s work, we were able to make some important discoveries that highlight previously unknown aspects of the immune response to influenza, which we will now build on to examine how relevant they are to other viral infections of the lung, such as SARS-CoV-2 and RSV.”Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Krishnaswamy KasturiranganFOLLOW

Krishnaswamy kasturirangan, Latest News

Mumbai, Sep 1 Even as the Indian National Developmental Inclusive Alliance (INDIA) on Friday announced a 14 member ... ...

Washington DC [US], September 1 : Higher levels of inflammation in the blood of obese patients after bariatric surgery ... ...

Chhatrapati Sambhajinagar: The organization 'TCS' which is charging exorbitant fees from the candidates for the Talathi recruitment exam has ... ...

Earlier the tournament was inaugurated by NDFA member Dr Kamal Ansari in the presence of AB Kha and Adnan ... ...

Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not ... ...

Chandigarh, Sep 1 The Shiromani Akali Dal (SAD), once a BJP ally, on Friday said it favoured the ... ...

Pallekele [Sri Lanka], September 1 : Pakistan on Friday announced their playing XI for the electrifying clash against arch-rival ... ...

Washington DC [US], September 1 : Researchers have uncovered some novel and unexpected ways that influenza virus and viral ... ...