Max planck institute for molecular biomedicine, Research institute in Münster, Germany

Anesthesia is a state of controlled, temporary loss of sensation or awareness that is induced for medical purposes in humans. But can plants also be given anaesthesia? A recent study has explored this possibility.The study was published in the journal 'Scientific Reports'.Medicine has a broad repertoire of anaesthetics at its medication allows patients to better endure painful treatments or even sleep through them. As early as 1842, ether was first used for a dental treatment in New York. Since then, this anaesthetic has served as one of the main anaesthetics worldwide for over 100 years.Remarkably, anaesthetisation is also possible in plants. Claude Bernard proved in 1878 that the touch-sensitive plant Mimosa pudica did not react to touch under the influence of ether by closing its leaves. He concluded that plants and mals must have a common biological essence that is disturbed by anaesthetics.Ether anaesthetics were used during surgery, childbirth and in palliative treatment to take away patients' pain. However, the exact mechsm of action has never been elucidated. Even with modern anaesthetics, it has been often unclear as to how and where they function. One reason for this is certainly that humans are a very delicate research subject.This is where plant researchers from Julius-Maximilians-Universitat (JMU) Wurzburg in Bavaria, Germany, stepped in. Professor Rainer Hedrich's team has been leading research on the Venus flytrap for over ten years. He has already achieved many groundbreaking insights into the life of this carnivorous plant."Unlike most other plants, the Venus flytrap is particularly sensitive to touch. In response to such stimuli, electrical impulses are triggered and transmitted extremely quickly to catch mal prey," Hedrich explained.The electrical impulses (action potentials, APs) of the flytrap are comparable to those of our nervous system. It is true that plants do not have a distinct nervous system. But they do transmit electrical information in their conductive tissue, for example, to close the trap at lightning speed: "In 2016, we were able to show that the Venus flytrap, like a human, can not only perceive touch but also count and remember the APs it has fired," explained the Wurzburg professor. "So it made sense to test whether and how ether affects the carnivorous plant's sense of touch."Before anaesthetising the plant, however, there were some tricky hurdles to overcome in order to be able to use the highly explosive ether gas."Explosions resulting in death, unfortunately, occurred repeatedly in the medical use of ether. That's why we had an explosion-protected device made so that we could work safely without blowing up the whole institute," reported Dr Sonke Scherzer with a grin.This way, the Wurzburg researchers found out that the Venus flytrap can be anaesthetised, similar to a human being, and that it does not react to touch during this time. Investigations of the trap memory even showed that the trap cannot "remember" touches during anaesthesia. Thus, its reaction is not different from that of a patient, as Hedrich's team reported in the study."Things got really exciting, however, when we discovered that the anaesthetised traps can perceive touch locally, but cannot transmit it," said Sonke Scherzer, the first author of the paper.Every touch of the sensory hairs leads to the release of the signal molecule calcium in the Venus flytrap. This molecule also played a decisive role in the transmission of stimuli in humans.In the plant, however, the JMU researchers were able to make the calcium signal visible by expressing genetically encoded calcium sensors. They found that the calcium signal is still produced in the sensory hairs of anaesthetised plants after a touch, but that it no longer leaves this touch sensor. Ether, therefore, interrupted the transmission of stimuli."Now we finally knew in which tissue the ether acts," said Sonke Scherzer. But in order to understand the exact mechsm of action of the anaesthesia, the Wurzburg researchers studied these hairs in detail and found out that only the hairs of fully-grown traps trigger the fast calcium signal when touched. Immature traps, on the other hand, do not have this signal and therefore cannot catch any prey."Now we have looked at how these two developmental stages differ and have come across an interesting gene that is found exclusively in the hairs of adult traps," said Rainer Hedrich. This gene encodes a glutamate receptor, which is apparently responsible for the rapid transmission of stimuli. These receptors perceive the neurotransmitter glutamate and are also found in humans, where they are involved in the transmission of stimuli in the synapses.Here, the plant researchers received support from Professor Manfred Heckmann, an expert on mal glutamate receptors at JMU Wurzburg. "Indeed, we see calcium signals when we stimulate the traps externally with glutamate," said Heckmann. "However, this response does not occur in anaesthetised traps or immature traps without the glutamate receptor expressed. Thus, the glutamate receptor appears to be a likely target in ether anaesthesia. When this receptor is blocked, stimulus transmission also stops.""Now we need to find out what the glutamate receptors of mals and plants have in common and how they differ," Heckmann outlined ongoing experimental research."With this paper, we show that the Venus flytrap can serve as a study object not only for plant research but also for medicine. With it, it could be possible to investigate the mechsm of action of drugs without having to conduct mal experiments," Scherzer held out the prospect.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

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Anesthesia is a state of controlled, temporary loss of sensation or awareness that is induced for medical purposes in humans. But can plants also be given anaesthesia? A recent study has explored this possibility. ...