Information technology and industry, Public university in London, England

Around 50 per cent of patients who have been hospitalised with severe COVID-19 and who show raised levels of a protein called troponin cause damage to their hearts.The injury was detected by magnetic resonance imaging (MRI) scans at least a month after discharge, according to new findings published today (Thursday) in the European Heart JournalDamage includes inflammation of the heart muscle (myocarditis), scarring or death of heart tissue (infarction), restricted blood supply to the heart (ischaemia) and combinations of all three.The study of 148 patients from six acute hospitals in London is the largest study to date to investigate convalescing COVID-19 patients who had raised troponin levels indicating a possible problem with the heart.Troponin is released into the blood when the heart muscle is injured. Raised levels can occur when an artery becomes blocked or there is inflammation of the heart. Many patients who are hospitalised with COVID-19 have raised troponin levels during the critical illness phase, when the body mounts an exaggerated immune response to the infection. Troponin levels were elevated in all the patients in this study who were then followed up with MRI scans of the heart after discharge in order to understand the causes and extent of the damage.Professor Marianna Fontana, professor of cardiology at University College London (UK), who led the research together with Dr. Graham Cole, a consultant cardiologist at Imperial College London, said: "Raised troponin levels are associated with worse outcomes in COVID-19 patients. Patients with severe COVID-19 disease often have pre-existing heart-related health problems including diabetes, raised blood pressure, and obesity.""During severe COVID-19 infection, however, the heart may also be directly affected. Unpicking how the heart can become damaged is difficult, but MRI scans of the heart can identify different patterns of injury, which may enable us to make more accurate diagnoses and to target treatments more effectively," added FontanaThe researchers investigated COVID-19 patients discharged up until June 2020 from six hospitals across three NHS London trusts: Royal Free London NHS Foundation Trust, Imperial College Healthcare NHS Trust, and University College London Hospital NHS Foundation Trust.Patients who had abnormal troponin levels were offered an MRI scan of the heart after discharge and were compared with those from a control group of patients who had not had COVID-19, as well as from 40 healthy volunteers."The recovering COVID-19 patients had been very ill; all required hospitalisation and all had troponin elevation, with around one in three having been on a ventilator in the intensive care unit," said Prof. Fontana."We found evidence of high rates of heart muscle injury that could be seen on the scans a month or two after discharge. Whilst some of this may have been pre-existing, MRI scanning shows that some were new, and likely caused by COVID-19. Importantly, the pattern of damage to the heart was variable, suggesting that the heart is at risk of different types of injury. While we detected only a small amount of ongoing injury, we saw injury to the heart that was present even when the heart's pumping function was not impaired and might not have been picked up by other techniques. In the most severe cases, there are concerns that this injury may increase the risks of heart failure in the future, but more work is needed to investigate this further."The function of the heart's left ventricle, the chamber that is responsible for pumping oxygenated blood to all parts of the body, was normal in 89 percent of the 148 patients but scarring or injury to the heart muscle was present in 80 patients (54 per cent). The pattern of tissue scarring or injury originated from inflammation in 39 patients (26 per cent), ischaemic heart disease, which includes infarction or ischaemia, in 32 patients (22 per cent), or both in nine patients (6 per cent). Twelve patients (8 per cent) appeared to have ongoing heart inflammation.Prof. Fontana said: "Injury relating to inflammation and scarring of the heart is common in COVID-19 patients with troponin elevation discharged from hospital, but is of limited extent and has little consequence for the heart's function."These findings give us two opportunities: firstly, to find ways of preventing the injury in the first place, and from some of the patterns we have seen, blood clotting may be playing a role, for which we have potential treatments. Secondly, detecting the consequences of injury during convalescence may identify subjects who would benefit from specific supporting drug treatments to protect heart function over time."The findings of the study are limited by the nature of patient selection and included only those who survived a coronavirus infection that required hospital admission."The convalescent patients in this study had severe COVID-19 disease and our results say nothing about what happens to people who are not hospitalised with COVID, or those who are hospitalised but without elevated troponin. The findings indicate potential ways to identify patients at higher or lower risk and suggest potential strategies that may improve outcomes. More work is needed, and MRI scans of the heart have shown how useful it is in investigating patients with troponin elevation," concluded Prof. Fontana.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Information Technology And IndustryFOLLOW

Information technology and industry, Latest News

Ahmedabad, Feb 20 England and India players have begun training at the refurbished Sardar Patel Stadium in Motera ... ...

Ahmedabad, Feb 19 England pace bowler Mark Wood on Friday said that family and fitness were the reasons ... ...

England pacer Mark Wood on Friday said he pulled out of the Indian Premier League (IPL) 2021 to prioritise his family and to be available for his side for the next assignment. ...

Ahead of the third Test against England, India all-rounder Hardik Pandya posted his picture with Motera Stadium in the background on social media and said it was a "surreal" experience to be at the world's largest cricket stadium. ...

Another 12,057 people in Britain have tested positive for COVID-19, bringing the total number of coronavirus cases in the country to 4,083,242, according to official figures released Thursday. ...

New Delhi, Feb 18 England left-arm fast bowler Sam Curran, who was supposed to join the England squad ... ...

New Delhi, Feb 18 It is difficult to ask players to not play in the Indian Premier League ... ...

Around 50 per cent of patients who have been hospitalised with severe COVID-19 and who show raised levels of a protein called troponin cause damage to their hearts. ...